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Article

Probing the aggregated effects of purifying selection per individual on 1,380 medical phenotypes in the UK Biobank.

PLoS genetics - 1 Jan 2021

Vy Ha My T, Jordan Daniel M, Balick Daniel J, Do Ron

Abstract excerpt

Understanding the relationship between natural selection and phenotypic variation has been a long-standing challenge in human population genetics. With the emergence of biobank-scale datasets, along with new statistical metrics to approximate strength of purifying selection at the variant level, it is now possible to correlate a proxy of individual relative fitness with a range of medical phenotypes. We...

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Identifiers

PMID: 33493176
DOI: 10.1371/journal.pgen.1009337
PMCID: PMC7861521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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