Article

Stochastic modelling and inference for mitochondria in health and disease

2018-01-01

Abstract excerpt

Mitochondria are crucial organelles for complex cellular life: their dysfunction causes multiple devastating heritable diseases, and is associated with healthy ageing. Cells possess a population of mitochondrial DNAs (mtDNA) which are continuously turned over. Consequently, mtDNA mutations may arise and expand throughout the cell. Here, we aim to use stochastic modelling to deepen our understanding of mitochondria...

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Literature Corpus work: 94f99041-01b3-5ac7-bd5c-4c378a78e352
DOI: 10.25560/65792

Open publication

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