Article

Mitochondrial network state scales mtDNA genetic dynamics

2018-09-05

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations cause severe congenital diseases but may also be associated with healthy aging. MtDNA is stochastically replicated and degraded, and exists within organelles which undergo dynamic fusion and fission. The role of the resulting mitochondrial networks in the time evolution of the cellular proportion of mutated mtDNA molecules (heteroplasmy), and cell-to-cell variability in heteropl...

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Literature Corpus work: 21813256-dbbf-543a-b362-bf41849661e0
DOI: 10.1101/409128

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