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Article

The rise and rise of mitochondrial DNA mutations.

Open biology - 1 May 2020

Lawless Conor, Greaves Laura, Reeve Amy K, Turnbull Doug M, Vincent Amy E

Abstract excerpt

How mitochondrial DNA mutations clonally expand in an individual cell is a question that has perplexed mitochondrial biologists for decades. A growing body of literature indicates that mitochondrial DNA mutations play a major role in ageing, metabolic diseases, neurodegenerative diseases, neuromuscular disorders and cancers. Importantly, this process of clonal expansion occurs for both inherited and somatic...

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Identifiers

PMID: 32428418
DOI: 10.1098/rsob.200061
PMCID: PMC7276526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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