Article

Evolution of cell-to-cell variability in stochastic, controlled, heteroplasmic mtDNA populations

2016-08-30

Abstract excerpt

Populations of physiologically vital mitochondrial DNA (mtDNA) molecules evolve in cells under control from the nucleus. The evolution of populations of mixed mtDNA types is complicated and poorly understood, and variability of these controlled admixtures plays a central role in the inheritance and onset of genetic disease. Here, we develop a mathematical theory describing the evolution and variability in these st...

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Literature Corpus work: 8a22187c-086b-5740-83f7-46a48fe1f473
DOI: 10.1101/072363

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