Article

Inferring Accumulation Times of Mitochondrial DNA Deletion Mutants from Cross-Sectional Single-Cell Data: Methodological Framework and Validation

2026-02-01

Abstract excerpt

The accumulation of mitochondrial DNA (mtDNA) deletion mutants in post-mitotic cells is a hallmark of mammalian ageing and a key contributor to tissue decline in skeletal muscle and neurons. Although the occurrence of such deletions is well documented, the mechanisms by which they clonally expand to levels exceeding the threshold for respiratory chain dysfunction remain unresolved. A transcription-coupled replicat...

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Literature Corpus work: b42bfaa3-b4f7-59a3-b251-10cbaeb66d29
DOI: 10.64898/2026.01.30.702736

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