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Article

Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance.

PloS one - 1 Jan 2013

Tam Zhi Yang, Gruber Jan, Halliwell Barry, Gunawan Rudiyanto

Abstract excerpt

Accumulation of mitochondrial DNA (mtDNA) mutations has been implicated in a wide range of human pathologies, including neurodegenerative diseases, sarcopenia, and the aging process itself. In cells, mtDNA molecules are constantly turned over (i.e. replicated and degraded) and are also exchanged among mitochondria during the fusion and fission of these organelles. While the expansion of a mutant mtDNA population...

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Identifiers

PMID: 24146842
DOI: 10.1371/journal.pone.0076230
PMCID: PMC3795767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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