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Article

The road to rack and ruin: selecting deleterious mitochondrial DNA variants.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Jul 2014

Holt Ian J, Speijer Dave, Kirkwood Thomas B L

Abstract excerpt

Mitochondria constitute the major energy-producing compartment of the eukaryotic cell. These organelles contain many molecules of DNA that contribute only a handful of proteins required for energy production. Mutations in the DNA of mitochondria were identified as a cause of human disease a quarter of a century ago, and they have subsequently been implicated in ageing. The process whereby deleterious variants...

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Identifiers

PMID: 24864317
DOI: 10.1098/rstb.2013.0451
PMCID: PMC4032523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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