Article

Complex-phase stochastic modeling of mitochondrial heteroplasmy

2026-06-09

Abstract excerpt

<h4>Annotation</h4> Mitochondrial heteroplasmy —the coexistence of both wild-type and mutant copies of mitochondrial DNA (mtDNA) within a cell—is a key factor in the pathogenesis of mitochondrial diseases. Classical approaches, which rely solely on the scalar fraction of mutant DNA, fail to fully account for threshold effects, the stochastic nature of heteroplasmy dynamics, and tissue specificity. The aim of the...

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Literature Corpus work: f0dfd849-0408-5ec7-b891-8205f9304aa8
DOI: 10.64898/2026.06.07.730672

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