Article

Energetic costs of cellular and therapeutic control of stochastic mtDNA populations

2017-06-02

Abstract excerpt

<h4>Summary</h4> Mitochondrial DNA (mtDNA) copy numbers fluctuate over time due to stochastic cellular dynamics. Understanding mtDNA dynamics and the accumulation of mutations is vital for understanding mitochondrial-related diseases. Here, we use stochastic modelling to derive general results for the impact of cellular control on mtDNA populations, the cost to the cell of different mtDNA states, and the optimisa...

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Literature Corpus work: ed97a37e-37a9-522d-bf4a-7e70f59e88d9
DOI: 10.1101/145292

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