Article

Is there a role for the RNA-binding protein LARP1 in β-cells?

2020-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Mechanistic target of rapamycin complex 1 (mTORC1) is a cellular rheostat linking nutrient availability and growth factor to cellular protein translation. In pancreatic insulin secreting β-cells, mTORC1 deficiency or chronic hyperactivation leads to diabetes. mTORC1 complexes with La-related protein 1 (LARP1) to specifically regulate the expression of 5’ terminal oligopyrimidine tract (5’TOP) mR...

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Literature Corpus work: 94dbd8d1-34fe-5b89-a4a3-87a3d8e4dc51
DOI: 10.1101/2020.09.03.281832

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