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Article

S-adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells.

Hepatology (Baltimore, Md.) - 1 Feb 2022

Ramani Komal, Robinson Aaron E, Berlind Joshua, Fan Wei, Abeynayake Aushinie, Binek Aleksandra, Barbier-Torres Lucía, Noureddin Mazen, Nissen Nicholas N, Yildirim Zehra, Erbay Ebru, Mato José M, Van Eyk Jennifer E, Lu Shelly C

Abstract excerpt

BACKGROUND AND AIMS: Methionine adenosyltransferase 1A (MAT1A) is responsible for S-adenosylmethionine (SAMe) biosynthesis in the liver. Mice lacking Mat1a have hepatic SAMe depletion and develop NASH and HCC spontaneously. Several kinases are activated in Mat1a knockout (KO) mice livers. However, characterizing the phospho-proteome and determining whether they contribute to liver pathology remain open for study....

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Identifiers

PMID: 34449924
DOI: 10.1002/hep.32130
PMCID: PMC8766892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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