Article

Synergistic Combined-proteomics Guided Mapping strategy identifies mTOR mediated phosphorylation of LARP1 in nutrient responsiveness and dilated cardiomyopathy

2022-10-14

Abstract excerpt

Increased activity of the mammalian target of rapamycin (mTOR) signalling pathway, a crucial nutrient sensor, exacerbates ageing and ageing-related diseases, including cancer and heart failure. To further elucidate the physiological role of the serine/threonine kinase mTOR, we devised a novel tractable proteomics strategy that combines interaction proteomics, proximity-based proteomics and quantitative phosphoprot...

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Literature Corpus work: 7b9e6c12-745a-5100-b824-83b52b26d09a
DOI: 10.1101/2022.10.13.512080

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