Article

Cellular and molecular basis of leptin resistance

2023-08-26

Abstract excerpt

<h4>SUMMARY</h4> Obese humans and diet induced obese mice (DIO) have high leptin levels and fail to respond to the exogenous hormone suggesting that obesity is caused by leptin resistance, the pathogenesis of which is unknown. We found that leptin treatment reduced plasma levels of mTOR ligands leading us to hypothesize that mTOR activation might inhibit leptin signaling. Rapamycin, an mTOR inhibitor, reduced fat...

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Literature Corpus work: 7a8196cf-ebd0-5d36-8a42-5117ce43679f
DOI: 10.1101/2023.08.24.554526

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