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Article

Raptor regulates functional maturation of murine beta cells

9 Jun 2017

Abstract excerpt

Diabetes is associated with beta cell mass loss and islet dysfunctions. mTORC1 regulates beta cell survival, proliferation and function in physiological and pathological conditions, such as pregnancy and pancreatectomy. Here we show that deletion of Raptor, which is an essential component of mTORC1, in insulin-expressing cells promotes hypoinsulinemia and glucose intolerance. Raptor-deficient beta cells display...

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PMID: 28598424
DOI: 10.1038/ncomms15755

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