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Article

Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice.

EMBO reports - 1 Aug 2015

Zidek Laura M, Ackermann Tobias, Hartleben Götz, Eichwald Sabrina, Kortman Gertrud, Kiehntopf Michael, Leutz Achim, Sonenberg Nahum, Wang Zhao-Qi, von Maltzahn Julia, Müller Christine, Calkhoven Cornelis F

Abstract excerpt

The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptations in response to changes in nutrient supply. Major downstream targets of mTORC1 signalling are the mRNA translation regulators p70 ribosomal protein S6 kinase 1 (S6K1p70) and the 4E-binding proteins (4E-BPs). However, little is known about vertebrate mRNAs that are specifically controlled by mTORC1 signalling...

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Identifiers

PMID: 26113365
DOI: 10.15252/embr.201439837
PMCID: PMC4552494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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