Article

Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in non-alcoholic steatohepatitis and reversed by alternate day fasting

2021-11-17

Abstract excerpt

<h4>Background</h4> Currently, little is known about the mechanism(s) regulating global and specific protein translation during non-alcoholic steatohepatitis (NASH). <h4>Methods</h4> We used puromycin-labelling, polysome profiling, ChIPseq and ChIP-qPCR, and gene manipulation in vitro and in dietary mouse models of NASH in this study. <h4>Results</h4> Using unbiased label-free quantitative proteome, puromycin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e055089c-5555-5ca8-9f2f-15d15c4dbb93
DOI: 10.1101/2021.11.16.468891

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in non-alcoholic steatohepatitis and reversed by alternate day fastingDOI 10.1101/2021.11.16.468891Read

Systemic identification of functionally conserved lncRNA metabolic regulators in human and mouse liversSemantic proximity Read

Ribosome biogenesis: A central player in liver diseasesSemantic proximity Read

Emerging roles of RNA-binding proteins in fatty liver disease.Semantic proximity Read

Characterization of long non-coding RNA transcriptome in high-energy diet induced nonalcoholic steatohepatitis minipigsSemantic proximity Read

Enpp1 ameliorates NAFLD by regulating hepatocyte lipid metabolism through the AMPK/PPARα signaling pathwaySemantic proximity Read

Identification of Two Long Noncoding RNAs, Kcnq1ot1 and Rmst, as Biomarkers in Chronic Liver Diseases in MiceSemantic proximity Read

Modulation of Atg genes expression in aged rat liver, brain, and kidney by caloric restriction analyzed via single-nucleus/cell RNA sequencingSemantic proximity Read

Suppression of hepatic amino acid catabolism by the human-specific lncRNA hLMR1Semantic proximity Read

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.Semantic proximity Read

BAP1 modulates endoplasmic reticulum stress signaling and balances liver homeostasis and malignant progressionSemantic proximity Read

The Liver-Enriched Long Non-Coding RNA FAM99A Suppresses Tumorigenesis through Negative Regulation of Protein SynthesisSemantic proximity Read

Ribosome profiling reveals extensive translational alterations in steatohepatitis-associated hepatocellular carcinomaSemantic proximity Read