Back to search

Article

A new microphysiological system shows hypoxia primes human ISCs for interleukin-dependent rescue of stem cell activity

2023-02-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> Hypoxia in the intestinal epithelium can be caused by acute ischemic events or conditions like Inflammatory Bowel Disease (IBD) where immune cell infiltration produces ‘inflammatory hypoxia’, a chronic condition that starves the mucosa of oxygen. Epithelial regeneration after ischemia and IBD suggests intestinal stem cells (ISCs) are highly tolerant to acute and chron...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9491623f-93b5-50a6-9339-f0c6f79a0df0
DOI
10.1101/2023.01.31.524747
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A new microphysiological system shows hypoxia primes human ISCs for interleukin-dependent rescue of stem cell activityDOI 10.1101/2023.01.31.524747
Gut stem cells in tissue renewal and disease: methods, markers, and mythsSemantic proximity
Inflammatory memory restrains intestinal stem cell regenerationSemantic proximity
Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem CellsSemantic proximity
Development and Maintenance of Cancer Stem Cells under Chronic InflammationSemantic proximity
Epigenetic Reprogramming Alters Intestinal Stem Cell Fate in PouchitisSemantic proximity
A niche-dependent redox rheostat regulates epithelial stem cell fateSemantic proximity
Mesenchymal stromal/stem cells promote intestinal epithelium regeneration after chemotherapy-induced damageSemantic proximity
HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia.Semantic proximity
Defining a stem cell hierarchy in the intestine: markers, caveats and controversiesSemantic proximity
Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoidsSemantic proximity
Brief report: CD24 and CD44 mark human intestinal epithelial cell populations with characteristics of active and facultative stem cellsSemantic proximity
Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota InteractionSemantic proximity
Select a neighboring publication to make it the new centre.