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HOPX+ injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia.

American journal of physiology. Gastrointestinal and liver physiology - 1 Nov 2021

Stewart Amy Stieler, Schaaf Cecilia Renee, Luff Jennifer A, Freund John M, Becker Thomas C, Tufts Sara R, Robertson James B, Gonzalez Liara M

Abstract excerpt

Intestinal ischemia is a life-threatening emergency with mortality rates of 50%-80% due to epithelial cell death and resultant barrier loss. Loss of the epithelial barrier occurs in conditions including intestinal volvulus and neonatal necrotizing enterocolitis. Survival depends on effective epithelial repair; crypt-based intestinal epithelial stem cells (ISCs) are the source of epithelial renewal in homeostasis...

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Cell Proliferation
Epithelial Cells
Homeodomain Proteins
Intestinal Mucosa
Severity of Illness Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tissue Culture Techniques

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Open in PubMed Open full text

Identifiers

PMID: 34549599
DOI: 10.1152/ajpgi.00165.2021
PMCID: PMC8616590

Genes

HOPX
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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