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A niche-dependent redox rheostat regulates epithelial stem cell fate

2025-01-28

Abstract excerpt

<h4>SUMMARY</h4> The niche environment surrounding intestinal stem cells (ISCs) varies along the length of intestine and provides key cues that regulate stem cell fate. Here, we investigated the role of cellular redox balance in colonic ISC function. We show that hypoxia and Wnt signaling synergize to restrict the reactive oxygen species (ROS) generating enzyme NADPH oxidase 1 (NOX1) to the crypt base in the dist...

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Identifiers and source

Literature Corpus work
71f08527-d035-5b5f-b24f-d13989a3163e
DOI
10.1101/2025.01.26.634856
Open publication

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A niche-dependent redox rheostat regulates epithelial stem cell fateDOI 10.1101/2025.01.26.634856
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