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Defining a stem cell hierarchy in the intestine: markers, caveats and controversies

11 Feb 2016

Abstract excerpt

The past decade has appreciated rapid advance in identifying the once elusive intestinal stem cell (ISC) populations that fuel the continual renewal of the epithelial layer. This advance was largely driven by identification of novel stem cell marker genes, revealing the existence of quiescent, slowly- and active-cycling ISC populations. However, a critical barrier for translating this knowledge to human health...

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PMID: 26864260
DOI: 10.1113/jp271651

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