Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells

Abstract excerpt

The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. The responsive stem cell that mediates this process is unclear, in part because of a lack of in vitro models that recapitulate key epithelial changes that occur in vivo during damage and repair. Here, we identify a Hopx + colitis-associated regenerative stem cell (CARSC) population that...

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