Article

Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue

2022-03-22

Abstract excerpt

<title>Abstract</title> <p>Comprehensive analyses of genome-wide mutation profiles has revealed that specific anti-cancer drugs, such as 5-fluorouracil (5-FU), are highly mutagenic to cancer cells and cultured cells. The systemic administration of these chemotherapies presents a potential genotoxic hazard to healthy tissues, however, the true mutational impact on normal cells of patients is not known. Here, we ex...

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Literature Corpus work: 948848b1-0ae8-5559-8c4b-0ef759716902
DOI: 10.21203/rs.3.rs-1435993/v1

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