Article

Deficiency of nucleotide excision repair explains mutational signature observed in cancer

2017-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Nucleotide excision repair (NER) is one of the main DNA repair pathways that protect cells against genomic damage. Disruption of this pathway can contribute to the development of cancer and accelerate aging. Tumors deficient in NER are more sensitive to cisplatin treatment. Characterization of the mutational consequences of NER-deficiency may therefore provide important diagnostic opportunities....

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Literature Corpus work: 7d113643-0806-5bd5-b9ec-69d3b93b79f2
DOI: 10.1101/221168

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