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Article

Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue.

Nature communications - 7 Oct 2022

Kuijk Ewart, Kranenburg Onno, Cuppen Edwin, Van Hoeck Arne

Abstract excerpt

Genome-wide mutation analyses have revealed that specific anti-cancer drugs are highly mutagenic to cancer cells, but the mutational impact of anti-cancer therapies on normal cells is not known. Here, we examine genome-wide somatic mutation patterns in 42 healthy adult stem cells (ASCs) of the colon or the liver from 14 cancer patients (mean of 3.2 ASC per donor) that received systemic chemotherapy and/or local...

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Identifiers

PMID: 36207433
DOI: 10.1038/s41467-022-33663-5
PMCID: PMC9546852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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