Extensive and differential platinum chemotherapy mutagenesis in livers of children.

doi:10.1126/science.ady0339

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Article

Extensive and differential platinum chemotherapy mutagenesis in livers of children.

Science (New York, N.Y.) - 10 Sept 2026

Wenger Anna, Vannier Jean-Baptiste, Lee-Six Henry, Loesch Robin, Emanuelli Giulia, Dave Manas, Layeghifard Mehdi, Lawson Andrew R J, Abascal Federico, Nicola Pantelis A, Treger Taryn D, Ogbonnah Toochi, Parks Conor, Oliver Thomas R W, Kennedy Jonathan, Hodder Angus, Anderson Nathaniel D, Torres Silva Felipe Luz, Trinh Mi K, Dowe Thomas, Habarwaa Marwo, Sun James J, Assia-Zamora Sergio, Cortes-Cerisuelo Miriam, Jassem Wayel, Town Charlotte, Dhawan Anil, Jain Vandana, Straathof Karin, Deheragoda Maesha, Martincorena Iñigo, Palm Liina, Hutchinson J Ciaran, Coorens Tim H H, Trayers Claire, Yuneva Mariia, Heaton Nigel, Shlien Adam, Zen Yoh, Rouhani Foad J, Behjati Sam

Abstract excerpt

Childhood cancer survivors often experience late adverse effects that may be linked to chemotherapy mutagenesis. We studied chemotherapy mutagenesis in normal pediatric tissues using duplex sequencing (NanoSeq) to enable the detection of mutations from single DNA molecules. We found that platinum chemotherapeutics increased the mutation burdens of normal pediatric tissues to levels seen in adults. In the liver,...

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Topics

Child
Child, Preschool

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Antineoplastic Agents

Cisplatin

Liver

Mutagenesis

Mutation

Organoplatinum Compounds

Infant

Carboplatin

Animals

Mice

Female

Source

Open in PubMed

Identifiers

PMID: 42721248
DOI: 10.1126/science.ady0339

Provenance

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