Article

The Heterochromatin protein 1 is a master regulator in RNA splicing precision deficient in ulcerative colitis

2020-12-30

Abstract excerpt

Defects in RNA splicing have been linked to numerous human disorders, but remain poorly explored in inflammatory bowel disease (IBD). Here, we report that, in the gut epithelium of patients with ulcerative colitis (UC), the expression of the chromatin and alternative splicing regulator HP1γ is strongly reduced. Accordingly, inactivation of the HP1γ gene in the mouse gut triggered several IBD-like traits, including...

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Literature Corpus work: 947a0de4-4add-5ed4-b211-02d7b064fbc0
DOI: 10.1101/2020.12.30.424798

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