Article

Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis

2024-01-15

Abstract excerpt

<h4>ABSTRACT</h4> Inflammatory bowel disease (IBD) is a debilitating and relapsing chronic disease of the gastrointestinal tract affecting millions of people. Here, we investigated the expression and functions of poly (ADP-ribose) polymerase 14 (Parp14), an important regulatory protein in immune cells, using a biobank IBD patient cohort as well as two mouse models of colitis, i.e., the IBD-mimicking oral dextran...

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Literature Corpus work: 4bf9b437-2509-5883-9a8e-923ee4a6942c
DOI: 10.1101/2024.01.12.575356

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