LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes.

doi:10.1126/scitranslmed.abl6057

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Article

LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes.

Science translational medicine - 10 Aug 2022

Della Valle Francesco, Reddy Pradeep, Yamamoto Mako, Liu Peng, Saera-Vila Alfonso, Bensaddek Dalila, Zhang Huoming, Prieto Martinez Javier, Abassi Leila, Celii Mirko, Ocampo Alejandro, Nuñez Delicado Estrella, Mangiavacchi Arianna, Aiese Cigliano Riccardo, Rodriguez Esteban Concepcion, Horvath Steve, Izpisua Belmonte Juan Carlos, Orlando Valerio

Abstract excerpt

Constitutive heterochromatin is responsible for genome repression of DNA enriched in repetitive sequences, telomeres, and centromeres. During physiological and pathological premature aging, heterochromatin homeostasis is profoundly compromised. Here, we showed that LINE-1 (Long Interspersed Nuclear Element-1; L1) RNA accumulation was an early event in both typical and atypical human progeroid syndromes. L1 RNA...

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PMID: 35947677
DOI: 10.1126/scitranslmed.abl6057

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