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Article

Unraveling the mysteries of aging through a Hutchinson-Gilford progeria syndrome model.

Rejuvenation research - 1 Apr 2011

Serio Ryan N

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, deadly laminopathy. Research into its nature has provided valuable insights into understanding molecular mechanisms underlying cell senescence. Phenotypic changes in nuclear structure and heterochromatin, resulting from increased progerin production following overuse of a cryptic splice site in the LMNA gene have profound effects on cell cycle progression and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21208065
DOI: 10.1089/rej.2010.1088

Genes

LMNA

Provenance

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Unraveling the mysteries of aging through a Hutchinson-Gilford progeria syndrome model.PMID 21208065Read ↗

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Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.Semantic proximity Read ↗

Hutchinson-Gilford Progeria Syndrome: A Literature ReviewSemantic proximity Read ↗

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