Article
Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias.
Gastroenterology - 1 Apr 2007
Konishi Kazuo, Shen Lanlan, Wang Suna, Meltzer Stephen J, Harpaz Noam, Issa Jean-Pierre J
Abstract excerpt
BACKGROUND & AIMS: We previously reported that a high degree of age-related methylation was found in both the dysplastic and nondysplastic mucosa of patients with ulcerative colitis (UC). Whether this translates into hypermethylation in UC-associated cancers (UC-Cs) is not known. METHODS: We evaluated the methylation status of 11 genes (MINT1, 2, 31, hMLH1, p16, p14, MGMT, HPP1, SFRP1, ERalpha, and LINE-1) in 48...
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