Article

The Anaphase Promoting Complex targets the toxic protein Progerin for ubiquitin-dependent degradation via autophagy

2026-07-24

Abstract excerpt

<h4>ABSTRACT</h4> The premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS) results from the accumulation of progerin, a cytotoxic protein generated from a point mutation in the Lamin A/C gene, in the nuclear lamina. Upon the proper stimulation, cells degrade progerin, reversing cellular HGPS phenotypes; however, there is still a gap in our knowledge concerning which pathways are mediating progerin...

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Literature Corpus work: d91629bd-8686-5e56-80de-3d4b499eade2
DOI: 10.64898/2026.07.23.740245

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