Article

The HP1γ epigenetic silencer dampens IFN-γ response at the gut epithelial barrier

2022-12-27

Abstract excerpt

Interferon gamma (IFN-γ) plays central roles in the pathophysiology of inflammatory bowel disease (IBD), both activating inflammatory responses and immunosuppressive functions. However, the epigenetic mechanisms controlling the expression of IFN-γ responsive genes at the gut epithelial barrier are not well understood. In this study, we identified the epigenetic regulator HP1γ as a transcriptional repressor of the...

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Identifiers and source

Literature Corpus work: 36603cae-dc03-5163-ba66-c446230cef40
DOI: 10.1101/2022.12.27.522038

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