Article
Alzheimer's Disease Susceptibility Gene Apolipoprotein E (APOE) and Blood Biomarkers in UK Biobank (N = 395,769).
Journal of Alzheimer's disease : JAD - 1 Jan 2020
Ferguson Amy C, Tank Rachana, Lyall Laura M, Ward Joey, Celis-Morales Carlos, Strawbridge Rona, Ho Frederick, Whelan Christopher D, Gill Jason, Welsh Paul, Anderson Jana J, Mark Patrick B, Mackay Daniel F, Smith Daniel J, Pell Jill P, Cavanagh Jonathan, Sattar Naveed, Lyall Donald M
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative condition where the underlying etiology is still unclear. Investigating the potential influence of apolipoprotein E (APOE), a major genetic risk factor, on common blood biomarkers could provide a greater understanding of the mechanisms of AD and dementia risk. OBJECTIVE: Our objective was to conduct the largest (to date) single-protocol investigation of...
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