Article

ABCA1 activity is associated with reduced Alzheimer’s Disease risk in APOE ε4 non-carriers

2025-01-27

Abstract excerpt

<h4>Background and Objectives</h4> ABCA1 has been associated with Alzheimer’s Disease (AD) via large-scale genetic studies, but the mechanisms by which it impacts disease risk are unknown. ABCA1 catalyzes apolipoprotein lipidation in the central nervous system and is known to interact molecularly with ApoE. We explored whether variants altering ABCA1 activity depend on the presence of different APOE isoforms to mo...

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Literature Corpus work: 7dbe6df5-634e-58d4-a93d-0578f9ed16c3
DOI: 10.1101/2025.01.24.25321105

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