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Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank.

EBioMedicine - 1 Sept 2020

Lumsden Amanda L, Mulugeta Anwar, Zhou Ang, Hyppönen Elina

Abstract excerpt

BACKGROUND: The three main alleles of the APOE gene (ε4, ε3 and ε2) carry differential risks for conditions including Alzheimer's disease (AD) and cardiovascular disease. Due to their clinical significance, we explored disease associations of the APOE genotypes using a hypothesis-free, data-driven, phenome-wide association study (PheWAS) approach. METHODS: We used data from the UK Biobank to screen for...

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Identifiers

PMID: 32818802
DOI: 10.1016/j.ebiom.2020.102954
PMCID: PMC7452404

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