Article

High-density extracellular recordings from the interior of intact brain organoids enable automated high-throughput functional assay

2025-09-13

Abstract excerpt

<h4>ABSTRACT</h4> Bridging the gap between preclinical screening and clinical outcomes remains a major challenge in drug development for neurological disorders. Brain organoids, derived from human induced pluripotent stem cells, offer a scalable and physiologically relevant platform to model human neural circuits. We develop a fully automated system to record neural activity from the interior of intact human cort...

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Literature Corpus work: 19bcdd27-202b-5478-8299-fcb7e6430b7f
DOI: 10.1101/2025.09.12.675888

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