Article

Optimized high-throughput screening of non-coding variants identified from genome-wide association studies

2022-03-12

Abstract excerpt

The vast majority of disease-associated single nucleotide polymorphisms identified from genome-wide association study (GWAS) are localized in non-coding regions. A significant fraction of these variants impact transcription factors binding to enhancer elements and alter gene expression. To functionally interrogate the activity of such variants we developed snpSTARRseq, a high-throughput experimental method that ca...

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Literature Corpus work: 94301e25-2166-58a5-a032-fefed8c391d6
DOI: 10.1101/2022.03.11.483985

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