Article

An Integrative Analysis of Chromatin Interactions, Gene Expression and Genomic Variants Identifies 30 Likely Regulatory Variants in Prostate Cancer

2023-01-19

Abstract excerpt

Prostate cancer (PC) is the most frequently diagnosed non-skin cancer in the world. Previous studies showed that genomic alterations represent the most common mechanism for molecular alterations that cause the development and progression of PC. Great efforts have been done to identify common protein-coding genetic variations; however, the impact of non-coding variations including regulatory genetic variants is not...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7d56ebe4-0481-5ff9-978f-e31b33eb01b2
DOI: 10.20944/preprints202301.0343.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An Integrative Analysis of Chromatin Interactions, Gene Expression and Genomic Variants Identifies 30 Likely Regulatory Variants in Prostate CancerDOI 10.20944/preprints202301.0343.v1Read

A Comprehensive Investigation of Genomic Variants in Prostate Cancer Reveals 30 Putative Regulatory Variants.Semantic proximity Read

Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci.Semantic proximity Read

Gene regulatory mechanisms underpinning prostate cancer susceptibility.Semantic proximity Read

Chromatin interactions and candidate genes at ten prostate cancer risk loci.Semantic proximity Read

Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome.Semantic proximity Read

Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network.Semantic proximity Read

Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer.Semantic proximity Read

Mechanistic insights into genetic susceptibility to prostate cancer.Semantic proximity Read

In silico functional pathway annotation of 86 established prostate cancer risk variants.Semantic proximity Read

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans.Semantic proximity Read

Prostate cancer genomics by high-throughput technologies: genome-wide association study and sequencing analysis.Semantic proximity Read

Comprehensive functional annotation of 77 prostate cancer risk loci.Semantic proximity Read