Article
Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci.
The Prostate - 1 Sept 2015
Chen Haitao, Yu Hongjie, Wang Jianqing, Zhang Zheng, Gao Zhengrong, Chen Zhuo, Lu Yulan, Liu Wennuan, Jiang Deke, Zheng S Lilly, Wei Gong-Hong, Issacs William B, Feng Junjie, Xu Jianfeng
Abstract excerpt
BACKGROUND: More than 100 prostate cancer (PCa) risk-associated single nucleotide polymorphisms (SNPs) have been identified by genome wide association studies (GWAS). However, the molecular mechanisms are unclear for most of these SNPs. METHODS: All reported PCa risk-associated SNPs reaching the genome-wide significance level of P < 1 × 10(-7) (index SNPs), as well as SNPs in linkage disequilibrium (LD, r(2) ≥...
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