Article
Functional annotation of risk loci identified through genome-wide association studies for prostate cancer.
The Prostate - 15 Jun 2011
Lu Yizhen, Zhang Zheng, Yu Hongjie, Zheng S Lily, Isaacs William B, Xu Jianfeng, Sun Jielin
Abstract excerpt
BACKGROUND: The majority of established prostate cancer (PCa) risk-associated single nucleotide polymorphisms (SNPs) identified from genome-wide association studies do not fall into protein coding regions. Therefore, the mechanisms by which these SNPs affect PCa risk remain unclear. Here, we used a series of bioinformatic tools and databases to provide possible molecular insights into the actions of risk SNPs....
Topics
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Linkage Disequilibrium
- Male
- Polymorphism, Single Nucleotide
- Prostatic Neoplasms
- Receptors, Androgen