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Article

Integrative identification of non-coding regulatory regions driving metastatic prostate cancer.

Cell reports - 24 Sept 2024

Woo Brian J, Moussavi-Baygi Ruhollah, Karner Heather, Karimzadeh Mehran, Yousefi Hassan, Lee Sean, Garcia Kristle, Joshi Tanvi, Yin Keyi, Navickas Albertas, Gilbert Luke A, Wang Bo, Asgharian Hosseinali, Feng Felix Y, Goodarzi Hani

Abstract excerpt

Large-scale sequencing efforts have been undertaken to understand the mutational landscape of the coding genome. However, the vast majority of variants occur within non-coding genomic regions. We designed an integrative computational and experimental framework to identify recurrently mutated non-coding regulatory regions that drive tumor progression. Applying this framework to sequencing data from a large...

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Share to Cell Line, Tumor
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Neoplasm Metastasis

Share to Prostatic Neoplasms

Share to Prostatic Neoplasms, Castration-Resistant

Share to Regulatory Sequences, Nucleic Acid

Share to RNA Splicing Factors

Source

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Identifiers

PMID: 39276353
DOI: 10.1016/j.celrep.2024.114764
PMCID: PMC11466230

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