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Article

High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing.

Nature communications - 22 May 2018

Zhang Peng, Xia Ji-Han, Zhu Jing, Gao Ping, Tian Yi-Jun, Du Meijun, Guo Yong-Chen, Suleman Sufyan, Zhang Qin, Kohli Manish, Tillmans Lori S, Thibodeau Stephen N, French Amy J, Cerhan James R, Wang Li-Dong, Wei Gong-Hong, Wang Liang

Abstract excerpt

Functional characterization of disease-causing variants at risk loci has been a significant challenge. Here we report a high-throughput single-nucleotide polymorphisms sequencing (SNPs-seq) technology to simultaneously screen hundreds to thousands of SNPs for their allele-dependent protein-binding differences. This technology takes advantage of higher retention rate of protein-bound DNA oligos in protein...

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Identifiers

PMID: 29789573
DOI: 10.1038/s41467-018-04451-x
PMCID: PMC5964124

Genes

ASCL2
RGS17

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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