Article

Mammalian mitochondrial mutational spectrum as a hallmark of cellular and organismal aging

2019-03-26

Abstract excerpt

Mutational spectrum of the mitochondrial genome (mtDNA) does not resemble signatures of any known mutagens and variation in mtDNA mutational spectra between different tissues and organisms is still incomprehensible. Since mitochondria is tightly involved in aerobic energy production, it is expected that mtDNA mutational spectra may be affected by the oxidative damage which is increasing with cellular and organisma...

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Literature Corpus work: 94143696-d27c-59c6-8b6d-3d409153aa0e
DOI: 10.1101/589168

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