Article
Multifactorial nature of high frequency of mitochondrial DNA mutations in somatic mammalian cells.
Biochemistry. Biokhimiia - 1 Sept 2009
Todorov I N, Todorov G I
Abstract excerpt
The high frequency of mitochondrial DNA (mtDNA) mutations in somatic mammalian cells, which is more than two orders of magnitude higher than the mutation frequency of nuclear DNA (nDNA), significantly correlates with development of a variety of mitochondrial diseases (neurodegenerative diseases, cardiomyopathies, type II diabetes mellitus, cancer, etc.). A direct cause-consequence relationship has been...
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