Article
A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand.
Nucleic acids research - 14 Oct 2022
Mikhailova Alina G, Mikhailova Alina A, Ushakova Kristina, Tretiakov Evgeny O, Iliushchenko Dmitrii, Shamansky Victor, Lobanova Valeria, Kozenkov Ivan, Efimenko Bogdan, Yurchenko Andrey A, Kozenkova Elena, Zdobnov Evgeny M, Makeev Vsevolod, Yurov Valerian, Tanaka Masashi, Gostimskaya Irina, Fleischmann Zoe, Annis Sofia, Franco Melissa, Wasko Kevin, Denisov Stepan, Kunz Wolfram S, Knorre Dmitry, Mazunin Ilya, Nikolaev Sergey, Fellay Jacques, Reymond Alexandre, Khrapko Konstantin, Gunbin Konstantin, Popadin Konstantin
Abstract excerpt
The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondria are responsible for aerobic respiration, it is expected that mtDNA mutational spectrum is affected by oxidative damage. Assuming that oxidative damage increases...
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