Article

Mitochondrial mutation spectrum in Chordates: damage versus replication signatures, causes, and dynamics

2023-12-11

Abstract excerpt

To elucidate the primary factors shaping mitochondrial DNA (mtDNA) mutagenesis, we derived a comprehensive 192-component mtDNA mutational spectrum using 86,149 polymorphic synonymous mutations reconstructed from the CytB gene of 967 chordate species. The mtDNA spectrum analysis provided numerous findings on repair and mutation processes, breaking it down into three main signatures: (i) symmetrical, evenly distribu...

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Literature Corpus work: b0eb9914-8fb0-5b9b-8c87-97ffca7f6153
DOI: 10.1101/2023.12.08.570826

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