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Article

Understanding the impact of mitochondrial DNA mutations on aging and carcinogenesis (Review).

International journal of molecular medicine - 1 Aug 2025

Kobayashi Hiroshi, Imanaka Shogo

Abstract excerpt

Mitochondria and mitochondrial DNA (mtDNA) are crucial for cellular energy metabolism and the adaptive response to environmental changes. mtDNA collaborates with the nuclear genome to regulate mitochondrial function. Dysfunctional mitochondria and mutations in mtDNA are implicated in a wide range of diseases, including mitochondrial disorders, neurodegenerative conditions, age‑associated pathologies and cancer....

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Topics

Humans
DNA, Mitochondrial
Aging
Mutation
Carcinogenesis
Animals
Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mitochondria

Source

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Identifiers

PMID: 40476552
DOI: 10.3892/ijmm.2025.5559
PMCID: PMC12176274

Provenance

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