Article

A mitochondria-specific mutational signature of aging: increased rate of A>G substitutions on a heavy chain

2021-12-07

Abstract excerpt

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondria is tightly involved in aerobic energy production, it is expected that mtDNA mutational spectra is affected by the oxidative damage. Assuming that oxidative damage in...

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Literature Corpus work: 444be003-6b40-5a7f-ad85-21c240b981ba
DOI: 10.1101/2021.12.03.460832

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