Article

Mitochondrial DNA mutations in human oocytes undergo frequency-dependent selection but do not increase with age

2024-12-12

Abstract excerpt

<h4>Summary</h4> Mitochondria, cellular powerhouses, harbor DNA (mtDNA) inherited from the mothers. MtDNA mutations can cause diseases, yet whether they increase with age in human germline cells—oocytes—remains understudied. Here, using highly accurate duplex sequencing of full-length mtDNA, we detected de novo mutations in single oocytes, blood, and saliva in women between 20 and 42 years of age. We found that,...

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Literature Corpus work: 3e472069-cc30-5d45-8560-de47c75be961
DOI: 10.1101/2024.12.09.627454

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